Microcrystalline Cellulose

What exactly is the ideal excipient? The one which helps make ingestion easier for customers and manufacturing simpler for producers. Not just an excipient which is permissible to use, but one that stretches beyond standard functionality. Microcrystalline cellulose may be the exact filling agent you are searching for. It won't gel like methyl-cellulose and if compared to other bulking agents it appears to provide the optimal degree of brittleness whilst staying lubricant sensitive.

Main Benefits

The main benefits of Microcrystalline Cellulose are:

• Very compressable
• Increased Flow
• Strong Filler for Encapsulation
• Non-reactive
• Low-absorption
• Industry standard in encapsulation

Which Grade is Best for You?

LFA Machines is able to offer you 5 different grades of Microcrystalline Cellulose. The grade names are 101, 102, 200, 301, and 302. You may be most familiar with our Microcrystalline Cellulose 102 grade which we can offer to you at 1kg, 2kg, 5kg, 10kg, and 20kg bags.

Some noticible differences between the grades are the following:

• Microcrystalline Cellulose 101 has the finest of particles, with a bulk density of 0.296g/cm³ . It is most suitable for wet granulation with excellent direct compression
• Microcrystalline Cellulose 102 has an average particle size with a bulk density of 0.308g/cm³ and is the most common grade of Microcrystalline Cellulose used in encapsulation.
• Microcrystalline Cellulose 200 has a larger than average particle size, with its bulk density being 0.282g/cm³. Grade 200 has superior flowing properties and is commonly used to correct API flow deficiencies.
• Microcrystalline Cellulose 301 is very similar to Microcrystalline Cellulose 101, but has a larger bulk density of 0.358g/cm³
• Microcrystalline Cellulose 302 is very similar to Microcrystalline Cellulose 102, but has a larger bulk density of 0.359g/cm³

Microcrystalline Cellulose, generally named MCC, is produced in a controlled environment. The end result is a pure, white powder without any taste or smell, able to add bulk and flow to your formula. MCC maintains the necessary advantages of a diluent. It is effective as a bulking agent in your capsules or tablets, giving the desirable weight for your customers. Microcrystalline cellulose has minimal bulk density, increasing flow characteristics. Easy flow helps to ensure that each ingredient is consistently spread throughout a mixture. If the mix is consistent, each capsule will have the same quantity of each ingredient at the end of production, creating a quality product.

Microcrystalline Cellulose really does its job, and also it does it well. It works well with many other popular excipients and is a integral part of many manufacturers formulas. Filling and Flow Agents undoubtedly are a crucial element in the encapsulation process simply because they ensure an accurate capsule weight.

Compressibility and binding are both unquestionable characteristics of Microcrystalline Cellulose. Neither of these characteristics deter its ability to dissolve with ease once in tablet form, a crucial element of any tablet or capsule. MCC is safe to consume in normal amounts, and broadly used as an excipient for tableting. Additionally it is a natural source of dietary fiber and is also non-caloric. Above all else, MCC is inert, meaning it will not react to or interfere with other substances.

Overall, this product could possibly be what you are searching for. It is sought-after since it is amongst the top diluents with outstanding bulking qualities, and will also preserve these properties for you. Your process of formation will become easier as a result of this ingredient. With its advantages and uses, Microcrystalline Cellulose is your ideal choice for a bulking agent. Using MCC alongside other excipients makes production run smoothly and efficiently.

Name	MCC 101	MCC 102	MCC 200	MCC 301	MCC 302
CAS number	9004-34-6
Molecular formula	(C6H10O5)n
Appearance	Fine white powder
Physical state	Solid
Storage	Store at room temperature
Melting point	260–270 °C; 500–518 °F
Bulk Density	0.296g/cm3	0.308g/cm3	0.282g/cm3	0.358g/cm3	0.359g/cm3
Tapped Density	0.453g/cm3	0.455 g/cm3	0.454 g/cm3	0.452g/cm3	0.453g/cm3
Solubility in water	None
Documents	Intolerance Data Technical Specification